Biocatalytic Conversion of Avermectin to 4″-Oxo-Avermectin: Improvement of Cytochrome P450 Monooxygenase Specificity by Directed Evolution

Discovery of the CYP107Z subfamily of cytochrome P450 oxidases (CYPs) led to an alternative biocatalytic synthesis of 4″-oxo-avermectin, a key intermediate for the commercial production of the semisynthetic insecticide emamectin. However, under industrial process conditions, these wild-type CYPs sho...

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Auteurs principaux: Trefzer, Axel, Jungmann, Volker, Molnár, István, Botejue, Ajit, Buckel, Dagmar, Frey, Gerhard, Hill, D. Steven, Jörg, Mario, Ligon, James M., Mason, Dylan, Moore, David, Pachlatko, J. Paul, Richardson, Toby H., Spangenberg, Petra, Wall, Mark A., Zirkle, Ross, Stege, Justin T.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2007
Sujets:
Enzymology and Protein Engineering
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932781/
https://ncbi.nlm.nih.gov/pubmed/17483257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02676-06
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