Biocatalytic Conversion of Avermectin to 4"-Oxo-Avermectin: Characterization of Biocatalytically Active Bacterial Strains and of Cytochrome P450 Monooxygenase Enzymes and Their Genes

4"-Oxo-avermectin is a key intermediate in the manufacture of the agriculturally important insecticide emamectin benzoate from the natural product avermectin. Seventeen biocatalytically active Streptomyces strains with the ability to oxidize avermectin to 4"-oxo-avermectin in a regioselect...

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Main Authors: Jungmann, Volker, Molnár, István, Hammer, Philip E., Hill, D. Steven, Zirkle, Ross, Buckel, Thomas G., Buckel, Dagmar, Ligon, James M., Pachlatko, J. Paul
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Enzymology and Protein Engineering
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1287622/
https://ncbi.nlm.nih.gov/pubmed/16269732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.71.11.6968-6976.2005
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