Breaking an Absolute Species Barrier: Transgenic Mice Expressing the Mink PrP Gene Are Susceptible to Transmissible Mink Encephalopathy

Transmissible mink encephalopathy (TME) is a rare disease of the North American mink, which has never been successfully transmitted to laboratory mice. We generated transgenic mice expressing the mink prion protein (PrP) and inoculated them with TME or the mouse-adapted scrapie strain 79A. TME infec...

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Auteurs principaux: Windl, O., Buchholz, M., Neubauer, A., Schulz-Schaeffer, W., Groschup, M., Walter, S., Arendt, S., Neumann, M., Voss, A. K., Kretzschmar, H. A.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1287601/
https://ncbi.nlm.nih.gov/pubmed/16282497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.23.14971-14975.2005
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