Pathogenicity of Influenza Viruses with Genes from the 1918 Pandemic Virus: Functional Roles of Alveolar Macrophages and Neutrophils in Limiting Virus Replication and Mortality in Mice

The Spanish influenza pandemic of 1918 to 1919 swept the globe and resulted in the deaths of at least 20 million people. The basis of the pulmonary damage and high lethality caused by the 1918 H1N1 influenza virus remains largely unknown. Recombinant influenza viruses bearing the 1918 influenza viru...

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Detalhes bibliográficos
Main Authors: Tumpey, Terrence M., García-Sastre, Adolfo, Taubenberger, Jeffery K., Palese, Peter, Swayne, David E., Pantin-Jackwood, Mary J., Schultz-Cherry, Stacey, Solórzano, Alicia, Van Rooijen, Nico, Katz, Jacqueline M., Basler, Christopher F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1287592/
https://ncbi.nlm.nih.gov/pubmed/16282492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.23.14933-14944.2005
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