Human T-Cell Leukemia Virus Type 1 Expressing Nonoverlapping Tax and Rex Genes Replicates and Immortalizes Primary Human T Lymphocytes but Fails To Replicate and Persist In Vivo

Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus associated primarily with adult T-cell leukemia and neurological disease. HTLV-1 encodes the positive trans-regulatory proteins Tax and Rex, both of which are essential for viral replication. Tax activates transcription initiatio...

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Bibliografiska uppgifter
Huvudupphovsmän: Younis, Ihab, Yamamoto, Brenda, Phipps, Andrew, Green, Patrick L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2005
Ämnen:
Transformation and Oncogenesis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1287553/
https://ncbi.nlm.nih.gov/pubmed/16282446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.23.14473-14481.2005
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