Dual Targeting of DNA Gyrase and Topoisomerase IV: Target Interactions of Garenoxacin (BMS-284756, T-3811ME), a New Desfluoroquinolone

We determined the target enzyme interactions of garenoxacin (BMS-284756, T-3811ME), a novel desfluoroquinolone, in Staphylococcus aureus by genetic and biochemical studies. We found garenoxacin to be four- to eightfold more active than ciprofloxacin against wild-type S. aureus. A single topoisomeras...

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Bibliografiset tiedot
Päätekijät: Ince, Dilek, Zhang, Xiamei, Silver, L. Christine, Hooper, David C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2002
Aiheet:
Mechanisms of Resistance
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC128724/
https://ncbi.nlm.nih.gov/pubmed/12384338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.11.3370-3380.2002
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