Resistance to β-Lactamase Inhibitor Protein Does Not Parallel Resistance to Clavulanic Acid in TEM β-Lactamase Mutants

In order to compare patterns of resistance to inhibition by clavulanic acid with patterns of resistance to inhibition by a β-lactamase inhibitor protein (BLIP), R164S, R244S, and R164S/R244S mutant forms of TEM β-lactamase were prepared by site-directed mutagenesis. When kinetic parameters were dete...

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הוצא לאור ב:	Antimicrob Agents Chemother
Principais autores:	Schroeder, William A., Locke, Troy R., Jensen, Susan E.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology (ASM) 2002
נושאים:	Mechanisms of Resistance
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128715/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12384366/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.11.3568-3573.2002
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