Replication of Putative Candidate-Gene Associations with Rheumatoid Arthritis in >4,000 Samples from North America and Sweden: Association of Susceptibility with PTPN22, CTLA4, and PADI4

Candidate-gene association studies in rheumatoid arthritis (RA) have lead to encouraging yet apparently inconsistent results. One explanation for the inconsistency is insufficient power to detect modest effects in the context of a low prior probability of a true effect. To overcome this limitation,...

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Hlavní autoři: Plenge, Robert M., Padyukov, Leonid, Remmers, Elaine F., Purcell, Shaun, Lee, Annette T., Karlson, Elizabeth W., Wolfe, Frederick, Kastner, Daniel L., Alfredsson, Lars, Altshuler, David, Gregersen, Peter K., Klareskog, Lars, Rioux, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society of Human Genetics 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1285162/
https://ncbi.nlm.nih.gov/pubmed/16380915
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