Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking

INTRODUCTION: PTPN22, PADI-4, and CTLA-4 have been associated with risk for rheumatoid arthritis (RA). We investigated whether polymorphisms in these genes were associated with RA in Caucasian women included in two large prospective cohorts, adjusting for confounding factors and testing for interact...

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Main Authors: Costenbader, Karen H, Chang, Shun-Chiao, De Vivo, Immaculata, Plenge, Robert, Karlson, Elizabeth W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483441/
https://ncbi.nlm.nih.gov/pubmed/18462498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2421
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