PKCɛ-mediated phosphorylation of vimentin controls integrin recycling and motility

PKCɛ controls the transport of endocytosed β1-integrins to the plasma membrane regulating directional cell motility. Vimentin, an intermediate filament protein upregulated upon epithelial cell transformation, is shown here to be a proximal PKCɛ target within the recycling integrin compartment. On in...

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Main Authors: Ivaska, Johanna, Vuoriluoto, Karoliina, Huovinen, Tuomas, Izawa, Ichiro, Inagaki, Masaki, Parker, Peter J
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2005
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283946/
https://ncbi.nlm.nih.gov/pubmed/16270034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600847
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