Cyclin H binding to the RARα activation function (AF)-2 domain directs phosphorylation of the AF-1 domain by cyclin-dependent kinase 7

The transcriptional activity of nuclear retinoic acid receptors (RARs), which act as RAR/retinoid X receptor (RXR) heterodimers, depends on two activation functions, AF-1 and AF-2, which are targets for phosphorylations and synergize for the activation of retinoic acid target genes. The N-terminal A...

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Autores principales: Bour, Gaétan, Gaillard, Emilie, Bruck, Nathalie, Lalevée, Sébastien, Plassat, Jean-Luc, Busso, Didier, Samama, Jean-Pierre, Rochette-Egly, Cécile
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2005
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283805/
https://ncbi.nlm.nih.gov/pubmed/16275922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505556102
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