Cholera Toxin and Heat-Labile Enterotoxin Activate Human Monocyte-Derived Dendritic Cells and Dominantly Inhibit Cytokine Production through a Cyclic AMP-Dependent Pathway

Cholera toxin (CT) and heat-labile enterotoxin (LT) are powerful mucosal adjuvants whose cellular targets and mechanism of action are unknown. There is emerging evidence that dendritic cells (DC) are one of the principal cell types that mediate the adjuvant effects of these toxins in vivo. Here we i...

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Main Authors: Bagley, Kenneth C., Abdelwahab, Sayed F., Tuskan, Robert G., Fouts, Timothy R., Lewis, George K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC128358/
https://ncbi.nlm.nih.gov/pubmed/12228279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.10.5533-5539.2002
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