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Invariant amino acids essential for decoding function of polypeptide release factor eRF1

In eukaryotic ribosome, the N domain of polypeptide release factor eRF1 is involved in decoding stop signals in mRNAs. However, structure of the decoding site remains obscure. Here, we specifically altered the stop codon recognition pattern of human eRF1 by point mutagenesis of the invariant Glu55 a...

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Main Authors: Kolosov, Petr, Frolova, Ludmila, Seit-Nebi, Alim, Dubovaya, Vera, Kononenko, Artem, Oparina, Nina, Justesen, Just, Efimov, Alexandr, Kisselev, Lev
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283522/
https://ncbi.nlm.nih.gov/pubmed/16282590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki927
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