Streptococcal Inhibitor of Complement Inhibits Two Additional Components of the Mucosal Innate Immune System: Secretory Leukocyte Proteinase Inhibitor and Lysozyme

Streptococcal inhibitor of complement (SIC) is a 31-kDa extracellular protein of a few, very virulent, strains of Streptococcus pyogenes (particularly M1 strains). It is secreted in large quantities (about 5 mg/liter) and inhibits complement lysis by blocking the membrane insertion site on C5b67. We...

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Detalhes bibliográficos
Main Authors: Fernie-King, Barbara A., Seilly, David J., Davies, Alexandra, Lachmann, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128256/
https://ncbi.nlm.nih.gov/pubmed/12183536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.9.4908-4916.2002
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