A Mutant of Burkholderia pseudomallei, Auxotrophic in the Branched Chain Amino Acid Biosynthetic Pathway, Is Attenuated and Protective in a Murine Model of Melioidosis

Using a transposon mutagenesis approach, we have identified a mutant of Burkholderia pseudomallei that is auxotrophic for branched chain amino acids. The transposon was shown to have interrupted the ilvI gene encoding the large subunit of the acetolactate synthase enzyme. Compared to the wild type,...

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Detalhes bibliográficos
Main Authors: Atkins, T., Prior, R. G., Mack, K., Russell, P., Nelson, M., Oyston, P. C. F., Dougan, G., Titball, R. W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128252/
https://ncbi.nlm.nih.gov/pubmed/12183585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.9.5290-5294.2002
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