Susceptibility of Nontypeable Haemophilus influenzae to Human β-Defensins Is Influenced by Lipooligosaccharide Acylation

Nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide htrB mutants exhibited greater than 45-fold-increased sensitivity to human β-defensin 2 (HBD-2) compared to the wild type. Complementation by htrB in trans to acylation competence reversed this increased sensitivity. In contrast, NTHI was...

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Detalhes bibliográficos
Main Authors: Starner, Timothy D., Swords, W. Edward, Apicella, Michael A., McCray, Paul B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128250/
https://ncbi.nlm.nih.gov/pubmed/12183584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.9.5287-5289.2002
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