Susceptibility of Nontypeable Haemophilus influenzae to Human β-Defensins Is Influenced by Lipooligosaccharide Acylation

Nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide htrB mutants exhibited greater than 45-fold-increased sensitivity to human β-defensin 2 (HBD-2) compared to the wild type. Complementation by htrB in trans to acylation competence reversed this increased sensitivity. In contrast, NTHI was...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Starner, Timothy D., Swords, W. Edward, Apicella, Michael A., McCray, Paul B.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128250/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12183584/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.9.5287-5289.2002
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