Increased Trypanosoma cruzi Invasion and Heart Fibrosis Associated with High Transforming Growth Factor β Levels in Mice Deficient in α(2)-Macroglobulin

Trypanosoma cruzi proteinases are involved in host cell invasion in human patients and in mouse models. In mice, murine α(2)-macroglobulin (MAM) and murinoglobulin are circulating plasma proteinase inhibitors that also have important roles in inflammation and immune modulation. To define their role...

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Detalhes bibliográficos
Main Authors: Waghabi, M. C., Coutinho, C. M. L. M., Soeiro, M. N. C., Pereira, M. C. S., Feige, J.-J., Keramidas, M., Cosson, A., Minoprio, P., Van Leuven, F., Araújo-Jorge, T. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128220/
https://ncbi.nlm.nih.gov/pubmed/12183561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.9.5115-5123.2002
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