Protection of Rhesus Macaques against Lethal Plasmodium knowlesi Malaria by a Heterologous DNA Priming and Poxvirus Boosting Immunization Regimen

We tested a cytokine-enhanced, multiantigen, DNA priming and poxvirus boosting vaccine regimen for prevention of malaria in the Plasmodium knowlesi-rhesus macaque model system. Animals were primed with a mixture of DNA plasmids encoding two preerythrocytic-stage proteins and two erythrocytic-stage p...

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Detalhes bibliográficos
Main Authors: Rogers, William O., Weiss, Walter R., Kumar, Anita, Aguiar, João C., Tine, John A., Gwadz, Robert, Harre, Joseph G., Gowda, Kalpana, Rathore, Dharmendar, Kumar, Sanjai, Hoffman, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128201/
https://ncbi.nlm.nih.gov/pubmed/12117942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.8.4329-4335.2002
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