Recurrent Variable Region Gene Usage and Somatic Mutation in the Human Antibody Response to the Capsular Polysaccharide of Streptococcus pneumoniae Type 23F

Combinatorial cloning and expression library analysis were used to isolate human antibody Fab fragments specific for the capsular polysaccharide of Streptococcus pneumoniae serotype 23F. Thirty 23F-specific Fabs were isolated from seven vaccinated donors, and the sequences of the heavy (H)- and ligh...

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Detalhes bibliográficos
Main Authors: Zhou, Jianhui, Lottenbach, Kathleen R., Barenkamp, Stephen J., Lucas, Alexander H., Reason, Donald C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128163/
https://ncbi.nlm.nih.gov/pubmed/12117915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.8.4083-4091.2002
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