Recurrent Variable Region Gene Usage and Somatic Mutation in the Human Antibody Response to the Capsular Polysaccharide of Streptococcus pneumoniae Type 23F

Combinatorial cloning and expression library analysis were used to isolate human antibody Fab fragments specific for the capsular polysaccharide of Streptococcus pneumoniae serotype 23F. Thirty 23F-specific Fabs were isolated from seven vaccinated donors, and the sequences of the heavy (H)- and ligh...

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Bibliografische Detailangaben

Veröffentlicht in:	Infect Immun
Hauptverfasser:	Zhou, Jianhui, Lottenbach, Kathleen R., Barenkamp, Stephen J., Lucas, Alexander H., Reason, Donald C.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Microbial Immunity and Vaccines
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128163/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12117915/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.8.4083-4091.2002
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