Human Monocytes Kill Shigella flexneri but Then Die by Apoptosis Associated with Suppression of Proinflammatory Cytokine Production

Shigella flexneri infection of human macrophages is followed by rapid bacterial escape into the cytosol and secretion of IpaB, which activates caspase-1 to mediate cell death and release of mature interleukin (IL)-1β. Here we report a different outcome following infection of human peripheral blood m...

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Main Authors: Hathaway, Lucy J., Griffin, George E., Sansonetti, Philippe J., Edgeworth, Jonathan D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC128053/
https://ncbi.nlm.nih.gov/pubmed/12065527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.7.3833-3842.2002
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