A Nuclear Surveillance Pathway for mRNAs with Defective Polyadenylation

The pap1-5 mutation in poly(A) polymerase causes rapid depletion of mRNAs at restrictive temperatures. Residual mRNAs are polyadenylated, indicating that Pap1-5p retains at least partial activity. In pap1-5 strains lacking Rrp6p, a nucleus-specific component of the exosome complex of 3′-5′ exonuclea...

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Bibliographic Details
Main Authors: Milligan, Laura, Torchet, Claire, Allmang, Christine, Shipman, Tracey, Tollervey, David
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280253/
https://ncbi.nlm.nih.gov/pubmed/16260613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.22.9996-10004.2005
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