Acquisition of Macrophage Tropism during the Pathogenesis of Feline Infectious Peritonitis Is Determined by Mutations in the Feline Coronavirus Spike Protein

In feline coronavirus (FCoV) pathogenesis, the ability to infect macrophages is an essential virulence factor. Whereas the low-virulence feline enteric coronavirus (FECV) isolates primarily replicate in the epithelial cells of the enteric tract, highly virulent feline infectious peritonitis virus (F...

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Autores principales: Rottier, Peter J. M., Nakamura, Kazuya, Schellen, Pepijn, Volders, Haukeline, Haijema, Bert Jan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280227/
https://ncbi.nlm.nih.gov/pubmed/16254347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.22.14122-14130.2005
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