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Kinetics Study of KPC-3, a Plasmid-Encoded Class A Carbapenem-Hydrolyzing β-Lactamase
The kinetic activity of KPC-3, a plasmid-encoded class A carbapenemase, was studied. It hydrolyzed penicillins, cephalosporins, carbapenems, and even sulbactam. The best substrate was cephalothin (k(cat/K)m = 3.48 μM(−1) s(−1)). The efficiency of the enzyme was similar for imipenem and meropenem (k(...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1280115/ https://ncbi.nlm.nih.gov/pubmed/16251324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.11.4760-4762.2005 |
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