Kinetics Study of KPC-3, a Plasmid-Encoded Class A Carbapenem-Hydrolyzing β-Lactamase

The kinetic activity of KPC-3, a plasmid-encoded class A carbapenemase, was studied. It hydrolyzed penicillins, cephalosporins, carbapenems, and even sulbactam. The best substrate was cephalothin (k(cat/K)m = 3.48 μM(−1) s(−1)). The efficiency of the enzyme was similar for imipenem and meropenem (k(...

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Библиографические подробности
Главные авторы: Alba, Jimena, Ishii, Yoshikazu, Thomson, Kenneth, Moland, Ellen Smith, Yamaguchi, Keizo
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2005
Предметы:
Mechanisms of Resistance
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280115/
https://ncbi.nlm.nih.gov/pubmed/16251324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.11.4760-4762.2005
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