Pirfenidone Blocks the In Vitro and In Vivo Effects of Staphylococcal Enterotoxin B

Pirfenidone [5-methyl-1-phenyl-2-(1H)-pyridone] down-regulates expression of cytokines and other mediators involved in the onset and development of pulmonary fibrosis. Pirfenidone also inhibits production of tumor necrosis factor alpha (TNF-α) from macrophages incubated with endotoxin and protects m...

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Detalles Bibliográficos

Publicado en:	Infect Immun
Autores principales:	Hale, Martha L., Margolin, Solomon B., Krakauer, Teresa, Roy, Chad J., Stiles, Bradley G.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2002
Materias:	Host Response and Inflammation
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127993/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12010989/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.6.2989-2994.2002
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