Pirfenidone Blocks the In Vitro and In Vivo Effects of Staphylococcal Enterotoxin B

Pirfenidone [5-methyl-1-phenyl-2-(1H)-pyridone] down-regulates expression of cytokines and other mediators involved in the onset and development of pulmonary fibrosis. Pirfenidone also inhibits production of tumor necrosis factor alpha (TNF-α) from macrophages incubated with endotoxin and protects m...

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Detalhes bibliográficos
Main Authors: Hale, Martha L., Margolin, Solomon B., Krakauer, Teresa, Roy, Chad J., Stiles, Bradley G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127993/
https://ncbi.nlm.nih.gov/pubmed/12010989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.6.2989-2994.2002
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