Construction and Phenotypic Characterization of an Auxotrophic Mutant of Mycobacterium tuberculosis Defective in l-Arginine Biosynthesis

A mutant of Mycobacterium tuberculosis defective in the metabolism of l-arginine was constructed by allelic exchange mutagenesis. The argF mutant strain required exogenous l-arginine for growth in vitro, and in the presence of 0.96 mM l-arginine, it achieved a growth rate and cell density in station...

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Detalhes bibliográficos
Main Authors: Gordhan, Bhavna G., Smith, Debbie A., Alderton, Heidi, McAdam, Ruth A., Bancroft, Gregory J., Mizrahi, Valerie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Bacterial Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127984/
https://ncbi.nlm.nih.gov/pubmed/12011001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.6.3080-3084.2002
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