Immunoglobulin G Monoclonal Antibodies to Cryptococcus neoformans Protect Mice Deficient in Complement Component C3

Passive administration of monoclonal antibodies (MAbs) to the capsular polysaccharide of Cryptococcus neoformans can alter the course of infection in mice. In a murine model of cryptococcal infection, immunoglobulin G1 (IgG1), IgG2a, and IgG2b switch variants of the anti-capsular 3E5 MAb prolong the...

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Autors principals: Shapiro, Scott, Beenhouwer, David O., Feldmesser, Marta, Taborda, Carlos, Carroll, Michael C., Casadevall, Arturo, Scharff, Matthew D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Fungal and Parasitic Infections
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC127925/
https://ncbi.nlm.nih.gov/pubmed/11953401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.5.2598-2604.2002
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