Inhibitors of Mitogen-Activated Protein Kinases Downregulate COX-2 Expression in Human Chondrocytes

Inducible prostaglandin synthase (cyclooxygenase-2, COX-2) is expressed in rheumatoid and osteoarthritic cartilage and produces high amounts of proinflammatory prostanoids in the joint. In the present study we investigated the effects of the inhibitors of mitogen-activated protein kinase (MAPK) path...

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Bibliografski detalji
Glavni autori: Nieminen, Riina, Leinonen, Sari, Lahti, Aleksi, Vuolteenaho, Katriina, Jalonen, Ulla, Kankaanranta, Hannu, B. Goldring, Mary, Moilanen, Eeva
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2005
Teme:
Research Communication
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1279039/
https://ncbi.nlm.nih.gov/pubmed/16258191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/MI.2005.249
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