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Sensitivities of Human Monocytes and Epithelial Cells to Pneumolysin Are Different

The Streptococcus pneumoniae pore-forming toxin, pneumolysin, is an important virulence factor in pneumococcal pneumonia. The effect of pneumolysin on human lung epithelial and monocyte cell viability was compared. Pneumolysin caused a dose-dependent loss of viability of human lung epithelial (A549...

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Published in:Infect Immun
Main Authors: Hirst, Robert A., Yesilkaya, Hasan, Clitheroe, Edwin, Rutman, Andrew, Dufty, Nichola, Mitchell, Timothy J., O’Callaghan, Christopher, Andrew, Peter W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2002
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127723/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11796644/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.2.1017-1022.2002
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