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DNA Adenine Methylase Overproduction in Yersinia pseudotuberculosis Alters YopE Expression and Secretion and Host Immune Responses to Infection

Yersinia pseudotuberculosis mutants that overproduce the DNA adenine methylase (Dam) are highly attenuated, confer fully protective immune responses, and secrete several Yersinia virulence proteins (Yersinia outer proteins [Yops]) under conditions that are nonpermissive for secretion in wild-type st...

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Bibliographic Details
Main Authors: Julio, Steven M., Heithoff, Douglas M., Sinsheimer, Robert L., Low, David A., Mahan, Michael J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC127708/
https://ncbi.nlm.nih.gov/pubmed/11796641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.2.1006-1009.2002
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