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Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim

Inhibitors of histone deacetylases (HDACIs) are a new generation of anticancer agents that selectively kill tumor cells. However, the molecular basis for their tumor selectivity is not well understood. We investigated the effects of HDACIs on the oncogenic Rb-E2F1 pathway, which is frequently deregu...

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Bibliografische gegevens
Hoofdauteurs: Zhao, Yan, Tan, Jing, Zhuang, Li, Jiang, Xia, Liu, Edison T., Yu, Qiang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2005
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276064/
https://ncbi.nlm.nih.gov/pubmed/16243973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505585102
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