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Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans

Choline is a required nutrient, and some humans deplete quickly when fed a low-choline diet, whereas others do not. Endogenous choline synthesis can spare some of the dietary requirement and requires one-carbon groups derived from folate metabolism. We examined whether major genetic variants of fola...

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Bibliografische gegevens
Hoofdauteurs: Kohlmeier, Martin, da Costa, Kerry-Ann, Fischer, Leslie M., Zeisel, Steven H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2005
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276051/
https://ncbi.nlm.nih.gov/pubmed/16236726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504285102
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