Central Role for Interleukin-4 in Regulating Nitric Oxide-Mediated Inhibition of T-Cell Proliferation and Gamma Interferon Production in Schistosomiasis

Schistosoma mansoni-infected wild-type (WT) mice develop a Th2 response and chronic disease. In contrast, infected interleukin-4 double-deficient (IL-4(−/−)) mice develop a Th1-like response and an acute, lethal syndrome. Disease severity in these animals correlates with excessive and prolonged prod...

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Detalhes bibliográficos
Main Authors: Patton, Elisabeth A., La Flamme, Anne C., Pedras-Vasoncelos, Joao A., Pearce, Edward J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127598/
https://ncbi.nlm.nih.gov/pubmed/11748180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.1.177-184.2002
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