Impaired Cutinase Secretion in Saccharomyces cerevisiae Induces Irregular Endoplasmic Reticulum (ER) Membrane Proliferation, Oxidative Stress, and ER-Associated Degradation

Impaired secretion of the hydrophobic CY028 cutinase invokes an unfolded protein response (UPR) in Saccharomyces cerevisiae cells. Here we show that the UPR in CY028-expressing S. cerevisiae cells is manifested as an aberrant morphology of the endoplasmic reticulum (ER) and as extensive membrane pro...

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Detalhes bibliográficos
Main Authors: Sagt, C. M. J., Müller, W. H., van der Heide, L., Boonstra, J., Verkleij, A. J., Verrips, C. T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Genetics and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127572/
https://ncbi.nlm.nih.gov/pubmed/11976084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.68.5.2155-2160.2002
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