Emergence of Resistance to Protease Inhibitor Amprenavir in Human Immunodeficiency Virus Type 1-Infected Patients: Selection of Four Alternative Viral Protease Genotypes and Influence of Viral Susceptibility to Coadministered Reverse Transcriptase Nucleoside Inhibitors

Previous data have indicated that the development of resistance to amprenavir, an inhibitor of the human immunodeficiency virus type 1 protease, is associated with the substitution of valine for isoleucine at residue 50 (I50V) in the viral protease. We present further findings from retrospective gen...

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Detalhes bibliográficos
Main Authors: Maguire, Michael, Shortino, Denise, Klein, Astrid, Harris, Wendy, Manohitharajah, Varsha, Tisdale, Margaret, Elston, Robert, Yeo, Jane, Randall, Sharon, Xu, Fan, Parker, Hayley, May, Jackie, Snowden, Wendy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127503/
https://ncbi.nlm.nih.gov/pubmed/11850255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.3.731-738.2002
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