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Emergence of Resistance to Protease Inhibitor Amprenavir in Human Immunodeficiency Virus Type 1-Infected Patients: Selection of Four Alternative Viral Protease Genotypes and Influence of Viral Susceptibility to Coadministered Reverse Transcriptase Nucleoside Inhibitors

Previous data have indicated that the development of resistance to amprenavir, an inhibitor of the human immunodeficiency virus type 1 protease, is associated with the substitution of valine for isoleucine at residue 50 (I50V) in the viral protease. We present further findings from retrospective gen...

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Wedi'i Gadw mewn:
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Maguire, Michael, Shortino, Denise, Klein, Astrid, Harris, Wendy, Manohitharajah, Varsha, Tisdale, Margaret, Elston, Robert, Yeo, Jane, Randall, Sharon, Xu, Fan, Parker, Hayley, May, Jackie, Snowden, Wendy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2002
Pynciau:
Antiviral Agents
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127503/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11850255/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.3.731-738.2002
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