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CD28 Is Required for Optimal Induction, but Not Maintenance, of Vaccine-Induced Immunity to Blastomyces dermatitidis

Cellular immunity mediated by T lymphocytes, in particular CD4(+) and CD8(+) type 1 cells, is the main defense against pathogenic fungi. Here, CD28-deficient (CD28(−/−)) mice were used to study the role of costimulation for the generation and maintenance of T-cell-mediated, type 1 cytokine-dependent...

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Autori principali: Wüthrich, Marcel, Warner, Tom, Klein, Bruce S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1273838/
https://ncbi.nlm.nih.gov/pubmed/16239544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.11.7436-7441.2005
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