Identification of Small-Molecule Inhibitors of Nucleoside Triphosphate Hydrolase in Toxoplasma gondii

Approximately 150,000 small-molecule compounds were tested by a robotic screening assay for their ability to inhibit nucleoside triphosphate hydrolase (NTPase), a novel enzyme of the tachyzoite form of Toxoplasma gondii. Five unrelated species of compounds were found to inhibit the activities of bot...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Asai, Takashi, Takeuchi, Tsutomu, Diffenderfer, Jeff, Sibley, L. David
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Mechanisms of Action: Physiological Effects
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127337/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12121910/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.8.2393-2399.2002
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