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Physiologically Based Pharmacokinetic Model for Terbinafine in Rats and Humans

The aim of this study was to develop a physiologically based pharmacokinetic (PB-PK) model capable of describing and predicting terbinafine concentrations in plasma and tissues in rats and humans. A PB-PK model consisting of 12 tissue and 2 blood compartments was developed using concentration-time d...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: Hosseini-Yeganeh, Mahboubeh, McLachlan, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127287/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12069977/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.7.2219-2228.2002
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