Neuroprotection and Reduced Proliferation of Microglia in Ribavirin-Treated Bornavirus-Infected Rats

In a rat model of Borna disease, intracerebral ribavirin caused clinical improvement without changes in virus titer or nucleic acid. Levels of microglia and infiltrating CD4 and CD8 cells were decreased, despite increases in mRNAs encoding interleukin-1β (IL-1β), IL-10, and gamma interferon in the b...

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Autors principals: Solbrig, Marylou V., Schlaberg, Robert, Briese, Thomas, Horscroft, Nigel, Lipkin, W. Ian
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC127284/
https://ncbi.nlm.nih.gov/pubmed/12069992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.7.2287-2291.2002
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