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Crystal Structure of (−)-Mefloquine Hydrochloride Reveals Consistency of Configuration with Biological Activity
The absolute configuration of (−)-mefloquine has been established as 11R,12S by X-ray crystallography of the hydrochloride salt, thus allowing comparison of the configuration of mefloquine's optical isomers to those of quinine and quinidine. (−)-Mefloquine has the same stereochemistry as quinin...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2002
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC127198/ https://ncbi.nlm.nih.gov/pubmed/11959592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.5.1529-1534.2002 |
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