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XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells
XRCC3 was inactivated in human cells by gene targeting. Consistent with its role in homologous recombination, XRCC3(−/−) cells showed a two-fold sensitivity to DNA cross-linking agents, a mild reduction in sister chromatid exchange, impaired Rad51 focus formation and elevated chromosome aberrations....
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1271813/ https://ncbi.nlm.nih.gov/pubmed/14749735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600087 |
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