Regulation of checkpoint kinases through dynamic interaction with Crb2

ATR/Rad3-like kinases promote the DNA damage checkpoint through regulating Chk1 that restrains the activation of cyclin-dependent kinases. In fission yeast, Crb2, a BRCT-domain protein that is similar to vertebrate 53BP1, plays a crucial role in establishing this checkpoint. We report here that Crb2...

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Hlavní autoři: Mochida, Satoru, Esashi, Fumiko, Aono, Nobuki, Tamai, Katsuyuki, O'Connell, Matthew J, Yanagida, Mitsuhiro
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1271744/
https://ncbi.nlm.nih.gov/pubmed/14739927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600018
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