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Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9
Transgenes stably integrated into cells or animals in many cases are silenced rapidly, probably under the influence of surrounding endogenous condensed chromatin. This gene silencing correlates with repressed chromatin structure marked by histone hypoacetylation, loss of methylation at H3 lysine 4,...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2004
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1271653/ https://ncbi.nlm.nih.gov/pubmed/14685282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600013 |
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