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Isomerization of the intersubunit disulphide-bond in Env controls retrovirus fusion

The membrane fusion activity of murine leukaemia virus Env is carried by the transmembrane (TM) and controlled by the peripheral (SU) subunit. We show here that all Env subunits of the virus form disulphide-linked SU–TM complexes that can be disrupted by treatment with NP-40, heat or urea, or by Ca(...

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Bibliografiske detaljer
Main Authors: Wallin, Michael, Ekström, Maria, Garoff, Henrik
Format: Artigo
Sprog:Inglês
Udgivet: 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1271652/
https://ncbi.nlm.nih.gov/pubmed/14685283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600012
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