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In Vitro and In Vivo Antifungal Activities of TAK-456, a Novel Oral Triazole with a Broad Antifungal Spectrum

TAK-456 is a novel oral triazole compound with potent and broad-spectrum in vitro antifungal activity and strong in vivo efficacy against Candida albicans and Aspergillus fumigatus. TAK-456 inhibited sterol synthesis of C. albicans and A. fumigatus by 50% at 3 to 11 ng/ml. TAK-456 showed strong in v...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Tsuchimori, Noboru, Hayashi, Ryogo, Kitamoto, Naomi, Asai, Kentaro, Kitazaki, Tomoyuki, Iizawa, Yuji, Itoh, Katsumi, Okonogi, Kenji
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2002
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127141/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11959573/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.5.1388-1393.2002
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