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Enhanced Inhibition of Orthopoxvirus Replication In Vitro by Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir

The nucleotide phosphonates cidofovir (CDV) and cyclic cidofovir (cCDV) are potent antiviral compounds when administered parenterally but are not well absorbed orally. These compounds have been reported to have activity against orthopoxvirus replication in vitro and in animal models when administere...

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Published in:Antimicrob Agents Chemother
Main Authors: Kern, Earl R., Hartline, Caroll, Harden, Emma, Keith, Kathy, Rodriguez, Natalie, Beadle, James R., Hostetler, Karl Y.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2002
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127114/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11897580/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.4.991-995.2002
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